Just run
$ context <myfile>
to compile documents. Post-installation, any files that are installed via <code>tlmgr</code> will automatically be found. However, because MkIV does not use the kpathsea library, some setup will be required whenever you install new files manually (without using <code>tlmgr</code>). After each such installation, each MkIV user must run: context --generate to refresh the ConTeXt disk cache data.
== MkIV cache location ==